Sugar uptake & breast cancer

Print edition : January 24, 2014

These phase contrast and confocal immunofluorescence images (inset) show 3D cultures of non-malignant (S1) and malignant (T4-2) breast cells in which glucose metabolism is inhibited by the addition of 2-deoxy-D-glucose (2DG). Supressing glucose uptake leads to a phenotypic reversion of malignant cells (they look normal) but does not affect non-malignant cells. Photo: University of California, Berkeley

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